Microarray and qPCR Analyses of Wallerian Degeneration in Rat Sciatic Nerves
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چکیده
منابع مشابه
Microarray and qPCR Analyses of Wallerian Degeneration in Rat Sciatic Nerves
Wallerian degeneration occurs immediately following injury to mammal peripheral nerves. To better understand the molecular events occurring during Wallerian degeneration, a rat model of sciatic nerve transection was used to assess differentially expressed genes at 0.5, 1, 6, 12, 24 h, 4 days, 1, 2, 3, and 4 weeks post nerve injury (PNI). Hierarchical clustering, Euclidean distance matrix, and p...
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Wallerian degeneration is an innate immune response which occurs after some kinds of nerve damages such as neurodegenerative disease and acute axonal injury. In clinic, dexamethasone as an anti-inflammatory drug has been used for many years to treat nerve injuries. In present study, we aimed to study the effects of various doses of dexamethasone on the Wallerian degeneration in rat. Twentyseven ...
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Wallerian degeneration is an important area of research in modern neuroscience. A large number of genes are differentially regulated in the various stages of Wallerian degeneration, especially during the early response. In this study, we analyzed gene expression in early Wallerian degeneration of the distal nerve stump at 0, 0.5, 1, 6, 12 and 24 hours after rat sciatic nerve injury using gene c...
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We used anti-phosphopeptide-immunodetecting antibodies as immunohistochemical reagents to define the location and activity state of p185(erbB2) during Wallerian degeneration. Nerve damage induces a phosphorylation event at Y1248, a site that couples p185(erbB2) to the Ras-Raf-MAP kinase signal transduction pathway. Phosphorylation of p185(erbB2) occurs within Schwann cells and coincides in time...
متن کاملThe Effect of Cortisone on Cell Proliferation and Migration in Peripheral Nerves undergoing Wallerian degeneration
T H E effect of cortisone on the proliferation of tissues other than mesenchymal has received little attention. Bullough (1952) showed that cortisone had a marked effect on the mitotic activity of the epidermis in mice, and Leroy (1952) showed a similar effect on immature testes of rats, but no effect on mature ones. McColl & Weston (1953) have studied the influence of cortisone on the process ...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2017
ISSN: 1662-5102
DOI: 10.3389/fncel.2017.00022